Basic Information:
Product Name: Kaempferol
IUPAC Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Molecular Formula: C15H10O6
Molecular Weight: 286.24 g/mol
CAS Number: 520-18-3
Physical Properties:
Appearance: Yellow crystalline powder
Melting Point: Approximately 276-278°C
Solubility: Poorly soluble in water; more soluble in organic solvents like ethanol, methanol, and DMSO
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Function:
Antibacterial Action: Inhibits the growth of enzymes and bacteria, including Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, and Shigella.
Respiratory Relief: Effective in treating cough and bronchitis.
Diabetic Cataract Treatment: Aids in the management of diabetic cataract.
Cell Proliferation Inhibition: At a concentration of 1 × 10^(-4) mol/L, it can inhibit cell proliferation.
Comprehensive Therapeutic Benefits: Primarily used for its anticancer properties, growth inhibition, anticonvulsant, anti-inflammatory, antioxidant, antispasmodic, anti-ulcer, choleretic, diuretic, and cough-relieving effects.
Application:
Kidney Health: Kaempferol promotes the growth of kidney cells (Opossum Kidney cells), stimulating kidney repair and up-regulating bone formation, which can be beneficial for treating chronic kidney disease and osteoporosis.
Cardioprotection: Inhibits H2O2-induced apoptosis in neonatal rat cardiomyocytes, likely due to its antioxidant properties and regulation of proteins such as Bcl-2, Bax, and Caspase-3.
Neuronal Protection: Acts as a blocker of voltage-gated potassium channels in the pyramidal neurons of the rat hippocampus, offering protective effects during acute hypoxia by stabilizing neuronal activity.
Antioxidant Benefits: Scavenges excessive superoxide free radicals, protecting DNA and cells from oxidative damage. Exhibits pharmacological effects including anti-tumor, anti-inflammatory, and anti-aging properties.
Wide-Ranging Effects: Demonstrates anticonvulsant, antispasmodic, anthelmintic, anti-ulcer, choleretic, diuretic, and cough-relieving activities.
