Basic Information:
English Name: 3,3'-Diindolylmethane
Other Name: 3-(1H-Indol-3-ylmethyl)-1H-indole; 3,3'-Methylenebis-1H-indole; DIM
Appearance: White or almost white powder
CAS No.: 1968-05-4
Molecular formula: C17H14N2
Function:
Hormonal Regulation:
Estrogen Metabolism: DIM influences the metabolism of estrogen, promoting a healthier balance between "good" estrogen metabolites (2-hydroxyestrone) and "bad" estrogen metabolites (16-hydroxyestrone), potentially reducing the risk of estrogen-related conditions.
Cancer Prevention:
Chemopreventive Properties: DIM has been studied for its ability to inhibit the growth of certain types of cancer cells, including breast, prostate, and colorectal cancers, through various mechanisms such as apoptosis (programmed cell death) and cell cycle arrest.
Anti-Inflammatory and Antioxidant Properties:
Reducing Inflammation: DIM may exhibit anti-inflammatory effects by modulating inflammatory pathways.
Antioxidant Activity: Acts as an antioxidant, helping protect cells from oxidative stress and damage.
Immune Support:
Immune Modulation: DIM might enhance the activity of certain immune cells, contributing to a more robust immune response.
Application:
Dietary Supplements:
Hormonal Balance: Formulated in supplements targeting hormonal health, particularly for conditions linked to estrogen dominance, such as premenstrual syndrome (PMS), menopause symptoms, and certain forms of hormonal acne.
Prostate Health: Included in supplements aimed at supporting prostate health in men.
Cancer Prevention: Marketed as part of a regimen to help reduce the risk of hormone-related cancers, based on its influence on estrogen metabolites and its anticancer properties.
Pharmaceutical Industry:
Therapeutic Research: Investigated in drug development and clinical studies for potential therapeutic applications in cancer treatment and prevention, as well as other hormonal and inflammatory conditions.
